If you’ve been following the latest in aesthetic medicine, you’ve likely heard the buzz about “Salmon DNA” injections. But as someone who trains other doctors on how to use this technology, I can tell you that Rejuran is much more than a catchy headline. It represents a fundamental shift in how we treat skin—moving away from just “filling” wrinkles and toward actually “healing” the skin at a cellular level.

Key Takeaways for Your Rejuran Journey

  • Cellular Regeneration, Not Just Volume: Unlike traditional fillers that provide instant but temporary volume, Rejuran (TGA ARTG ID: 412630) acts as a bio-modulator. It signals your fibroblasts to increase collagen and elastin production, with clinical data showing dermal thickness and density can increase by 15–30% within four weeks.
  • The “Protocol of Three”: Optimal results aren’t an overnight fix. For a true transformation in skin quality, a standard series of 3 sessions spaced 3–4 weeks apart is recommended. This cumulative approach allows the skin to reach its peak regenerative state, with visible improvements in texture and “glass skin” glow typically appearing by the second week.
  • Safety and Versatility: Because it is highly biocompatible and anti-inflammatory, Rejuran is suitable for sensitive skin and delicate areas where fillers might cause puffiness. Specifically, Rejuran I is tailored for the under-eye area, while Rejuran S is formulated with higher viscosity to effectively treat acne and surgical scars.

What is Rejuran, exactly?

At its core, Rejuran is a bio-modulator made of Polynucleotides (PN). These are essentially chains of nucleotides—the building blocks of DNA. 

When we introduce these highly purified DNA fragments into the dermis, they don’t just sit there like a dermal filler. Instead, they act as a biological signal. They “wake up” your fibroblasts—the factory cells responsible for collagen and elastin—and give them the blueprint and the energy to start repairing years of environmental damage.

Why are my patients at Shape Clinic so loyal to this treatment? It’s because Rejuran addresses the three things that topical creams often can’t reach:

  1. Tissue Regeneration: Through cellular signalling, it repairs skin from inside out by stimulating essential growth factors. 
  2. Anti-Inflammatory Action: Unlike many treatments that rely on “controlled injury” to see results, Rejuran actively calms the skin. This makesit a great treatment for those with sensitive skin or redness.
  3. Deep Hydration: Rejuran can have an “inner-moisturiser” effect that creates a luminous, dewy finish—the famous “Glass Skin” look.

How often do we need to treat with Rejuran?

Rejuran works best in a series. Think of it like going to the gym for your skin; one session is a great start, but a protocol of two to three sessions (spaced a few weeks apart) is where the real transformation happens.

Is Rejuran Right for You?

If you feel like your skin has lost its “snap,” if your pores look larger than they used to, or you’re looking to add the ‘glow’ factor to your skin, Rejuran might be the missing piece of your skin health puzzle.

The Hard Science: Clinical & Regulatory Insights

We don’t just rely on anecdotes; we rely on data. Rejuran is registered as a Class III medical device with Australia’s TGA (ARTG ID: 412630), substantiating its safety for professional skin rejuvenation.

  • Dermal Density: Clinical studies show that PN administration can significantly improve collagen density and skin elasticity by targeting cellular senescence.
  • Proven Efficacy: Recent research has demonstrated that these injections are associated with measurable improvements in periorbital appearance and high patient satisfaction.

The Shape Clinic Difference: Precision is Everything

While the product itself is revolutionary, the results are entirely dependent on the hand holding the syringe. This is where Shape Clinic sets the standard. Our boutique team of clinicians are highly trained, and we strategically deliver Rejuran at the exact depth, choosing between intricate micro-droplet techniques or advanced cannula techniques, to ensure that Rejuran is placed exactly where it needs to go.

At Shape Clinic, we believe in “I Shape Me”—the idea that your aesthetic journey should be informed, evidence-based, and uniquely yours.

Contact us to make a Rejuran or non-surgical medical aesthetics treatment booking today.

author avatar
Nicky Lurie Dermal Therapist
Nicky Lurie is a skin therapist with over 20 years of experience, specialising in medical aesthetics. She supports both our surgical and aesthetic services by delivering customised skincare solutions using medical-grade treatments. Nicky’s expertise ensures clients receive effective, evidence-backed products tailored to their specific needs, from acne to ageing.